The challenge to locate responsibility in ever more entangled and dynamic socio-technical environments is a key concern of the ONLIFE Manifesto. This contribution focuses specifically on responsibilities in processes of knowing, a topic which is discussed under the heading of epistemic responsibility in philosophy. I argue that two perspectives regarding epistemic responsibility should be distinguished: 1) the individualistic perspective, focusing on individuals as knowers within increasingly complex and dynamic socio-technical epistemic systems and 2) the governance perspective, focusing on the question how systems and environments should be designed so that individuals can act responsibly. Different fields of research have offered valuable insights for the development of a notion of epistemic responsibility in a hyperconnected era, most notably the fields of (social) epistemology, philosophy of computing as well as feminist theory of science and technology. From those insights, two major challenges can be deduced: 1) To acknowledge the socio-technical entanglement of knowers while at the same time striving to support responsibility assumption and attribution and 2) to be attentive to power asymmetries within entangled socio-technical environments.